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2014 Oct;84(4):821-5

For men: Starting doses typically range from 200-300 mcg daily, with potential increases to 400-500 mcg based on individual response and treatment goals

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In animal models, the elevated TMAO levels were significantly related to tubulointerstitial fibrosis and collagen deposition in the kidney and TMAO was demonstrated to increase in kidney injury molecule-1, phosphorylation of Smad3 (Tang et al., 2015b)

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These findings indicate KPV may protect the gut lining and modulate immune signaling