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The pKa value determined for the cysteine persulfide is 4.34, suggesting that the persulfurated cysteine residue is present in a negatively charged deprotonated state, aligning with the robust electrostatic interaction observed in this investigation

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[3] While the clinical relevance to humans remains under investigation, GLP-1 medications carry a boxed warning for MTC

9 The importance of the brain bioavailability of GLP-1 analogs is underscored by the prominent expression of the GLP-1R within the brain