One that is in late-stage trials but is already getting lots of headlines is retatrutide
Microdosing emerged from the community, not from clinical research
The STEP-1 extension trial followed patients who had lost weight on semaglutide and then switched to placebo
Psychoneuroendocrinology 103 , 284295 (2019)
By focusing on protein, fiber, exercise, gut health, and blood sugar stability, you can support the systems your body already uses to regulate appetite, energy, and metabolism
If possible, also track waist circumference weekly, body composition monthly (through DEXA or bioimpedance), and blood markers quarterly (fasting glucose, HbA1c, lipid panel, liver enzymes)