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ATTAIN-1 (NCT05869903) The key trial for the obesity indication, ATTAIN-1 randomized 3,127 adults with obesity or overweight (without diabetes) to orforglipron 6 mg, 12 mg, or 36 mg versus placebo for 72 weeks

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The interface area of GLP-1(9-36) with GLP-1R increases from 1,891 [GLP-1(9-36) alone] to 3,010 in the presence of LSN3318839, nearly matching that of GLP-1(7-36) (3,316 )