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The investigators identified 64,000+ adults aged 45 or older with overweight or obesity and atherosclerotic cardiovascular disease (prior heart attack, stroke, or peripheral artery disease) but no diabetes diagnosis, who initiated semaglutide or tirzepatide between May 2022 and January 2025

Table 1 Key regulators of glucagon secretion

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Marek Health was co-founded in 2021 by Derek, the creator of the More Plates More Dates YouTube channel, blog, and podcast, along with Mike Stratton

See, the most common mistake people make is diving into rigid, cookie-cutter plans that feel more like a straitjacket than a lifestyle change