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Across the SURPASS phase 3 programme versus placebo and active comparators, including semaglutide, tirzepatide has shown superior dose-dependent reductions in HbA1c levels up to 2.5% and body weight up to 13%, compared with all comparators [88-91]

Gantz, I

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Neuroprotection protocols use 0.25-0.5 mg daily subcutaneously or orally