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Wadden, PhDand funded by Novo Nordisk, the maker of semaglutidefound that GLP-1 users without known psychopathology werent any more likely to develop depression or suicidal thoughts or actions than controls

Lancet 398 (10313), 18111824

The biology suggests a possible positive feedback loop between GLP-1 and steroid hormone pathways

Importantly, brain endothelial cells are known to gain their specialized BBB functions through interactions with other cells of NVU such as pericytes, astrocytes, and neurons (Canfield et al., 2019), which is crucial for the development, regulation, maintenance of the neural barriers (Daneman et al., 2010a, b)

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