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In a substudy from the obesity trial, retatrutide was studied for liver fat change at 24 weeks in a defined participant subgroup, using imaging based endpoints

One difference between the medicines is that the Wegovy pill must be taken on an empty stomach with a small amount of water, and patients are directed not to eat, drink or take other medicines for 30 minutes after taking it

Theoretical concerns: These are large protein molecules that likely have low transfer to milk, and any medication that does get into breast milk would likely be digested in the infants stomach

This triggers a glucose-dependent release of insulin

It is already facing hundreds of lawsuits filed by patients who experienced severe side effects after taking Zepbound for weight loss