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5-fold weaker affinity than native GLP-1)
More extensive clinical trials are needed to shed more light on the effectiveness of retatrutide for T2D, and whether it may be limited due to the activation of the GCG receptors, which may exert anti-insulin effects
Below are general points to consider for each FDA-approved use
No apto para consumo humano
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Signals for disease modification Evidence for true disease modification remains low-certainty and hypothesis-generating, with recent observational signals serving as a foundation for potential disease modification rather than established therapeutic benefit (100)
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