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477 proteins were found to be differentially expressed (Supplemental Table 1), of which 302 proteins had a minimum fold change of 1.2 (Supplemental Table 2)

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Here we discuss the main ideas involved in modeling the transsulfuration pathway, referring the reader to [20] (and its online supplementary material) for a discussion of the other parts of the model

Autophagy, a conserved cellular process through which cells degrade their own components (e.g., organelles and proteins) via lysosomal activity to balance energy for survival [86], is linked to hepatic steatosis through impaired autophagic flux, whereas activating lysosomal autophagy can promote the clearance of hepatic lipid droplets, highlighting its potential in treating NAFLD/MAFLD [87]

Rusch M, Zimmermann TJ, Brger M, Dekker FJ, Grmer K, Triola G, Brockmeyer A, Janning P, Bttcher T, Sieber SA, et al

Transdermal patches Transdermal delivery systems using microneedles or permeation enhancers show promise for peptide delivery