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Micro-CT analysis further confirmed that the articular surface of hind paws was severely damaged, accompanied by osteophyte formation in the RA model group

Kidney problems: Diarrhea, nausea, and vomiting can cause dehydration, which may lead to kidney problems

Alternative Approach: For sensitive skin, a low-irritation vitamin C serum may be used before therapyjust proceed gradually and monitor for reactions

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If a respective model has limited metabolic capacity, the inclusion of both the parent chemical and the active metabolite(s) is relevant

A versatile collection of pyrimidine-2,4-diones has been reported as DPP-4 inhibitors, with trelagliptin, linagliptin, and alogliptin being well-established members of this group