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This is, on average, 2-3 months but could be shorter or longer

In addition to the physical protection provided by the skull, the brain is protected by a special biological barrier, including the BBB, blood-cerebrospinal fluid barrier (BCSFB), and cerebrospinal fluid-brain barrier (CSF-brain barrier) (Figure 1), among which the BBB has the lowest permeability

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median HbA1c, 7.4%)