Accordingly, selective targeting of GSH-dependent nodes (such as cysteine transport, mitochondrial GSH import, compartmentalized GSH degradation, or NADPH-dependent regeneration) may offer greater specificity and efficacy than indiscriminate redox perturbation
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Structurally, DSIP exhibits amphiphilic characteristics, meaning it has both hydrophilic (water-loving) and hydrophobic (water-hating) parts that enables it to interact with both hydrophilic and lipophilic cellular environments
Cystine transporter slc7a11/xCT in cancer: Ferroptosis, nutrient dependency, and cancer therapy