The problem is that the stomach doesn't always tolerate this well, especially at first
People think they have a nice insurance company, they dont even know what a PBM is, until they get sick, and then they have to put up with this
Similarly, BMI was related to mean overnight GH (r = 0.72, P = 0.006), basal GH secretion (r = 0.69, P = 0.009), and mean log10 peak GH area (r = 0.77, P = 0.002) and showed no relationship with GH half-life or number of GH peaks
That is actually a higher proportion of muscle loss than what retatrutide showed in its phase 2 data
But of more concern is really that it can cause receptor desensitization, maybe even turn off the whole receptor pathway
Long-term studies in animal models have examined whether chronic IGF1 LR3 use affects tumor growth or progression, an important consideration given the role of IGF-1 signaling in cancer biology