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Medicine 83 , 342347 (2004)

J.RonaiZ.Regulation of JNK signaling by GSTp.EMBO J;1999 171

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Reported Effects Increased pigmentation: Skin tanning via MC1R activation, typically observable after 510 daily injections [1]

This interval allows: GI side effects (nausea, vomiting, diarrhea) from the current dose level to subside The body to adapt to the rate of gastric emptying at that dose Clinicians to assess tolerability before increasing further Time to reach maximum dose week 20 (after five four-week steps: 1mg, 2mg, 4mg, 8mg, 12mg)

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