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Across all trials, 10,442 participants (44.2%) were female, participants mean HbA 1c at baseline was 66.6 mmol/mol (8.3%), mean body weight was 88.8 kg and mean age was 57.8 years (Table 1)

Once there, they inhibit the tyrosinase enzyme, which slows down the production of dark pigment

Lancet Gastroenterology & Hepatology

To be honest, I was not very familiar