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At low concentrations, these effects appear to be due to increased release of catecholamines (epinephrine and norepinephrine) as a result of antagonism of presynaptic receptors for adenosine

Being a sole IgG1 Fc fragment, efgartigimod is the only FcRn antagonist in the current clinical pipeline that does not harbor selected V regions specific for FcRn

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Altogether, these observations resurrected the issue of high-folatelow-vitamin B-12 interaction as a potential public health concern in the postfortification eraespecially in populations where supplement use is prevalent

Tradeoffs: Oral semaglutide has lower bioavailability and weaker clinical evidence than injectable

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