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The role of IGF-1 LR3 is validated by detecting pathological changes in intestinal tissue, barrier permeability, tight junction protein expression, and other indicators

A comprehensive overview of the specific signaling regulatory pathways is presented in Table 1

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GI Gastrointestinal IBD inflammatory bowel disease CCK cholecystokinin GIP glucose-dependent insulinotropic peptide GLP-1 glucagon-like peptide-1 PYY peptide YY MMCs migratory motor complexes GOAT ghrelin-O-acyltransferase GHSR growth hormone secretagogue receptor PC1/3 prohormone convertase 1/3 MBOAT membrane-bound O-acyltransferases HHAT hedgehog acyltransferase LEAP2 liver-expressed antimicrobial peptide 2 CNS central nervous system NTS nucleus tractus solitarius ARC arcuate nucleus NPY neuropeptide Y AgRP agouti-related peptide DVC dorsal vagal complex VTA ventral tegmental area POMC peptide pro-opiomelanocortin GABA gamma-aminobutyric acid AP area postrema PVN paraventricular nucleus GERD gastroesophageal reflux disease MCH melanin-concentrating hormone H

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