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doi:10.1074/jbc.274.13.8570

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Clin Cancer Res (2019) 25(23):691624

Clinical studies show that GLP-2 and GLP-3 often leads to greater weight loss than GLP-1

However, it's important to note that oral semaglutide (Rybelsus) must be taken on waking, in a fasting state, with a small amount of water, and at least 30 minutes before food, drink or other medications, as per its SmPC

The calculation requires four inputs: annual net revenues under exclusivity for each remaining year, post-LOE revenue trajectory (typically modeled as a percentage of pre-LOE revenues declining on a defined schedule), the date of LOE for each IP protection layer, and the discount rate