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DPPIV doesnt fully break down immunogenic peptides and isnt active at the low pH found in the gastric environment.31 Evidence regarding the ability of the enzymes AN-PEP and latiglutenase (formerly known as ALV003) to break down gluten into nonimmunogenic peptides in the gastric environment is more promising

This data supports a treatment paradigm in which patients could initiate treatment with potent injectable agents for maximal initial weight loss and then transition to oral orforglipron for long-term maintenance, reducing the burden of chronic injection therapy

Crucially, the development of generics will also increase the quantity of GLP-1 drugs made each year