ONeil PM, Birkenfeld AL, McGowan B, Mosenzon O, Pedersen SD, Wharton S, et al
The short answer: yes, you can use topical GHK-Cu alongside GLP-1 therapy without concern
Clinicians should evaluate for contraindications specific to GLP-1 receptor agonists, including: Personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 History of pancreatitis or gallbladder disease Severe gastroparesis or gastrointestinal disease History of suicidal ideation or behavior Pregnancy or planned pregnancy (pregnancy testing when appropriate) Diabetic retinopathy (requires monitoring in patients with diabetes) Baseline investigations should include TSH, free T4, complete metabolic panel, lipid profile, and hemoglobin A1c (if diabetic or prediabetic)
It says severe cases may involve pancreatitis symptoms, specifically acute abdominal pain, back pain and elevated pancreatic enzymes
Protective factors such as Nrf2 and SLC7A11/GPX4 can counteract this process by reducing oxidative damage (Wan et al., 2023)
Indias booming generic GLP-1 market has also become a target for counterfeiters