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The induction of SMADs via EV39 was notable, given that human intestinal organoid cultures typically require a TGF1 receptor inhibitor (A83-01) for long-term maintenance 105

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The presence of glycine residues in MRP7s binding site confers localized flexibility, presumably facilitating the binding of a variety of ligands and compensating for the proteins relative overall rigidity in comparison to MRP1

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