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Retatrutide's triple-agonist mechanism (GLP-1 + GIP + glucagon) produces diarrhea in approximately 34% of users at 12 mg, compared to roughly 30% for semaglutide at 2.4 mg

Once you pick a day, stick with it

Their depression improves in ways that seem to go beyond what youd expect from weight loss or appetite suppression alone

For example, somatostatin, a hormone principally produced in the nervous and digestive systems, reduces GLP-1 production

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