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RNS include free radicals like nitric oxide ( NO) and nitrogen dioxide ( NO 2 - ), as well as nonradicals such as peroxynitrite (ONOO - ), nitrous oxide (HNO 2 ) and alkyl peroxynitrates (RONOO) [8, 10]

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KPV is a tripeptide and the smallest species in the vial at 342.4 g/mol, so it is the component most readily lost to adsorption and to filtration or dialysis steps with a molecular weight cut-off

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To further demonstrate activation of the TSS pathway by DMF, we investigated the metabolism of serine for de novo cysteine biosynthesis by 13 C 3 -serine tracing (Fig