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Moreover, it enhanced Bcl-2 expression, attenuated p38 and JNK phosphorylation, and improved cardiac function in hypertensive rats, suggesting that exercise may play a protective role against hypertension-induced cardiac dysfunction by regulating cellular stress responses (OS, ERS, mitophagy, inflammatory response, and mitotic activation) ( 5.2.4 Exercise-mediated exerkines regulate mitophagy Exercise stimulates the release of specific endogenous cytokines, peptides, nucleic acids, and metabolites from skeletal muscle and other endocrine organs, collectively called exerkines, which have a crucial regulatory role in maintaining cellular functional homeostasis and quality control (Pedersen et al., 2004

Kelly AS, Auerbach P

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Gastric loads and cholecystokinin synergistically stimulate rat gastric vagal afferents

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