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Differential Diagnosis The clinical differential diagnosis of a common blue nevus includes traumatic tattoo, combined nevus, vascular lesions including venous lake and angiokeratoma, sclerosing hemangioma, primary and metastatic melanoma, pigmented spindle cell nevus, atypical nevus, dermatofibroma, papular pigmented basal cell carcinoma, and glomus tumor
Pelle E, Jian J, Declercq L, Dong K, Yang Q, Pourzand C, Maes D, Pernodet N, Yarosh DB, Huang X
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Stott, R
148,149 Literature shows that altered metabolism in neural cells through aberrant insulin signalling could be a reason for the synthesis of A protein and phosphorylated tau, which are two hallmark biochemical abnormalities linked with AD and proper regulation of insulin signalling has been observed to be a crucial approach in neuroprotection and guarding the synapses against noxious A deposition hence improving cognition in animal models of AD