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The latter typically occurs when reactive oxygen species, also known as harmful byproducts of metabolism, accumulate and affect DNA, proteins and lipids

Similar content being viewed by others Introduction Central to metabolic reprogramming is the dysregulation of Glutamine (Gln) metabolism, which has emerged as a critical aspect of cancer pathophysiology

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Some studies suggest that prolonged or excessive mTOR inhibition may impair muscle protein synthesis and potentially exacerbate sarcopenia in older adults, highlighting a possible trade-off between metabolic benefits and preservation of lean massan area requiring further investigation [28]

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