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A 2023 study in Diabetes, Obesity and Metabolism (Ludvik et al.) measured voluntary fluid intake in tirzepatide patients vs controls
Like other incretin-based therapies, tirzepatide can influence blood pressure and fluid balance and may cause a small increase in heart rate
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& Landry, J
4 How Mounjaro works Mounjaro activates two hormone receptors instead of one: Like Rybelsus, it activates the GLP-1 receptor It also activates GIP (glucose-dependent insulinotropic polypeptide), a second gut hormone involved in appetite regulation and blood sugar control This dual-action mechanism likely explains why tirzepatide produces greater weight loss and improvements in blood sugar in clinical trials than GLP-1-only medications