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The PK/PD relationship of covalent drugs For traditional small-molecule drugs, blood concentrations must be maintained at a specific level to sustain the pharmacological effect

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Kim SY, Nair MG

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Moreover, supplementation with Lactobacillus plantarum (DP189) and GOS restored gut microbial composition, improved gut and BBB integrity, reduced cortical inflammation and elevated acetylcholinesterase activity, reversing anxiety and depression-like behaviors in mice (Wang J

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Future research must integrate multi-omics analyses to identify biomarkers that can predict therapeutic responses, thereby determining which patients are more likely to benefit from different strategies such as mitochondrial transfer, antioxidant, or anti-inflammatory therapies

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Global prevalence of Helicobacter pylori infection and incidence of gastric cancer between 1980 and 2022

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