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Tirzepatide carries a boxed warning about thyroid C-cell tumors observed in rodent studies and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
References Raun K, Hansen BS, Johansen NL, Thgersen H, Madsen K, Ankersen M, et al
As SPHKAP has previously been shown to bind to the mitochondrial cristae junction regulator and MICOS complex component MIC19 40 , a prominent PKA substrate involved in both cristae assembly during mitochondrial remodelling 43 and in regulation of ERMCSs, we next tested whether exendin-4 stimulation would trigger MIC19 phosphorylation in WT INS-1 832/3 cells using a MIC19 immunoprecipitation strategy coupled with western blotting with an antibody against PKA phosphosites (RRxpS/T) 44
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