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Those who undergo GI surgery, like removal of intestines or gastric bypass, may also have difficulty with B12 absorption (4, 5)

A Cochrane review on folic acid supplements and cognition, with or without vitamin B12, did not find a significant effect of the supplements vs

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Neurodegeneration triggers peripheral immune cell recruitment into the forebrain

These are usually given to people who are deficient in B12 or have trouble absorbing it from food