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4.4 Interactions between cartilage and synovium 4.4.1 Interplay between cytokines released by chondrocytes and synovial cells When cartilage is damaged, chondrocytes release proteoglycan fragments, type II collagen fragments, and diverse injury-associated factors that synovial cell surface pattern recognition receptors (PRRs) can detect, prompting synovial hyperplasia and proinflammatory cytokine secretion (139)

Age (Dordr.) 38 , 26 (2016)

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Our results also indicate that senescent chondrocytes present a larger and flatter cell shape, which is consistent with a previous study (Cha et al., 2013)

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