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After injection, applying gentle pressure (without rubbing) for a few seconds can help seal the puncture and limit blood leakage

Since semaglutide is prescribed at higher doses for FDA-approved uses, your doctor might not support or recommend this method unless they see a specific need for it

Transdermal estradiol, delivered through patches or gels rather than oral tablets, bypasses the liver entirely, avoiding the first-pass hepatic metabolism that oral estrogen undergoes and that is associated with increased clotting factor production and thrombotic risk