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[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Tsai H-H, Liu C-J, Lee B-C, Chen Y-F, Yen R-F, Jeng J-S

The following relevant parameters were determined where possible: area under the concentration-time curve from time zero to the last time point (AUCo-iast) or extrapolated to infinity (AUCo- ), C ma x concentration in plasma extrapolated to time zero (Co), terminal elimination half-life (tj 2), volume of distribution (Vd), and clearance (CL)

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60,000 IU/month cholecalciferol), vitamin D supplementation led to a non-significant 9% reduction in major adverse cardiovascular events (MACE), driven primarily by myocardial infarction, while stroke outcomes remained unchanged ( 6.2 L-carnitine L-Carnitine supports mitochondrial fatty acid transport, and meta-analyses have shown modest lipid-lowering effects (e.g., reductions in LDL-C and triglycerides) at doses exceeding 2 g/day ( 6.3 Garlic extract Putative benefits include vasodilation via enhanced NO bioavailability, possible ACE inhibition, and antioxidant properties