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Accordingly, significant GHSR expression is observed in the brain areas that regulate food intake, such as the hypothalamus, brainstem, hippocampus, amygdala, and ventral tegmental area (VTA) (57, 58)

Many arguments suggest that we simply haven't performed the right study to find the benefit, but one could also argue that if multiple different studies didn't show a statistical difference, then the true benefit is likely modest, at best

Lazarou, M., Thorburn, D

It is a naturally occurring molecule at physiological doses

In cell proliferation assays, DES(1-3) IGF-1 is approximately 10-fold more potent than native IGF-1, but IGF-1 LR3 achieves even greater sustained activation because its prolonged presence continuously stimulates the receptor

Yes, a moderately low-carb approach (50-100 grams of carbs per day) is generally well tolerated and may benefit people with insulin resistance