"When I talk to patients about weight management, I always bring up these other options as well, because some people don't want to use a needle." Older prescription weight loss pills include: Hydrogel ( Plenity ) Naltrexone-bupropion ( Contrave ) Orlistat ( Xenical ) Phentermine (Adipex, Suprenza) Phentermine topiramate (Qsmyia) While the GLP-1 agonists can produce a weight loss of 10% to 20%, the average weight lost with older medications is lower in the range of 5% to 10% of the starting body weight
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GLP1 receptor agonists reduce hunger through three pathways that work simultaneously: Brain signaling : GLP1 receptors in the hypothalamus and brainstem regulate hunger and satiety
Diabetologia 64(12):26762686
Lind M, Imberg H, Coleman RL, Nerman O, Holman RR (2021) Historical HbA 1c values may explain the type 2 diabetes legacy effect: UKPDS 88
GLP-1 agonists are not indicated for type 1 diabetes