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While severe hypoglycemia is uncommon with tirzepatide monotherapy due to its glucose-dependent mechanism, combining it with other glucose-lowering agents or supplements increases risk

Implications for the hormonal control of gluconeogenesis and action of hypoglycaemic agents

Using smaller doses lowers these problems and makes the medication easier on the body

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doi: 10.1016/j.taap.2008.08.013 141 BridgesHRJonesAJPollakMNHirstJ