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Moreover, IONP-LPrA2 reduced PC tumorspheres (treated with 5-FU) via notch signaling and suggesting that leptin might be involved in reducing the cytotoxic effect of chemotherapeutic drug and facilitating chemoresistance [71]

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All animal experiments were approved by the Institutional Animal Care and Use Committee of Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine and were conducted in accordance with Guide for the Care and Use of Laboratory Animals (National Research Council 1996, USA)