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We discovered that Diphenyleneiodonium chloride (DPI), an inhibitor of flavoprotein enzymes and mitochondrial complex I, synergizes with mitoquinone mesylate (MitoQ), a mitochondria-targeted antioxidant in 2D and 3D in vitro models of NB

It also changed the structure of the cell membrane (SSC, side scatter) and cell size (FSC, forward scatter), increased the level of ROS and fluorescence of FITC conjugated with annexin V

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