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Unlike nitric oxide-based therapies such as phosphodiesterase type 5 inhibitors, which enhance blood flow through vasodilation, PT-141 stimulates sexual arousal through activation of melanocortin receptors in the brain and spinal cord

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Chem 405(8) , 2635-42, (2013) Hepatotoxicity of drug candidates is one of the major concerns in drug screening in early drug discovery

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