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Histamine (1-100 M, 12 h) inhibits the migration of microglia and the release of inflammatory mediator IL-1 in LPS (HY-D1056)-stimulated N9 mouse microglial, exhibits anti-inflammatory activity [5]

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Although the SELECT trial differs from the trials reviewed, most significantly in the recruitment of a population without diabetes (and hence potentially at lower baseline risk), it is encouraging that our calculated NNT 3P-MACE falls within the ranges reported, contributing to the face-validity of our analysis