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[5] Beyond sodium-channel antagonism, systemic lidocaine exhibits anti-inflammatory and antihyperalgesic properties attributed to inhibition of G-protein-coupled receptors, modulation of NMDA-mediated excitatory transmission, suppression of neutrophil priming, and attenuation of central glial activation

Robu and Lavandhomme, 2019)

This is because it helps improve the thickness of the skin, smoothens out the skin texture, and leads to a more excellent elasticity which also results in the prevention of fine lines and wrinkles

doi: 10.33549/physiolres.933776

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King et al