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These effects are not only dependent on mechanical load, because the skeletal muscle may serve as an endocrine organ that is capable of secreting cytokines to modulate bone metabolism [3, 4]
416,417,418 Frataxin activates persulfide transfer, which is essential for the assembly of ironsulfur clusters (FeS) in the mitochondria and the activity of the mitochondrial respiratory chain complex and other mitochondrial enzymes
Finally, the one-trial memory test, which specifically assessed exploratory behavior and recognition memory using novel and familiar objects, further corroborated these findings
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