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CJC-1295 without DAC is more precisely described as tetrasubstituted GRF(1-29), a 29-amino-acid fragment of growth hormone releasing hormone carrying four substitutions (D-Ala at position 2, Gln at 8, Ala at 15 and Leu at 27)

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This selective physiological impact highlights the complexity of interpreting toxicity beyond survival endpoints

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doi: 10.3389/fmicb.2022.881037 Received 22 February 2022 Accepted 11 March 2022 Published 14 April 2022 Volume 13 - 2022 Edited by Chun Cui, South China University of Technology, China Reviewed by Youqiang Xu, Beijing Technology and Business University, China