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Glutathione and sulfur amino acids in human health and disease Hoboken, Wiley,, 598 (2009)

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Overall, the certainty of the evidence for the evaluated outcomes was rated as low or very low due to study limitations and imprecise estimates

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Research indicates that optimal levels of glutathione are absolutely required to protect the integrity of mitochondrial DNA, which is highly vulnerable to oxidative mutation

The researchers showed that blocking glutamine metabolism through JHU083 not only suppressed tumor cell metabolism but also mitigated the tumor microenvironment, which is hostile to the immune response due to its hypoxic, acidic, and nutrient-depleted conditions, unleashing the natural antitumor T cell response