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In animal and laboratory research, melatonin has been shown to reverse age-related muscle dysfunction of the gallbladder and improve inflammation and gallbladder function in acute cholecystitis (Gomez-Pinilla 2006

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The abdomen (avoiding a two-inch radius around the navel) and front and outer thighs are appropriate sites for self-injection

Yes, with proper screening

These include: Nausea (affecting 20-40% of patients, though often transient) Vomiting and diarrhoea Constipation Abdominal pain and bloating Reduced appetite (which, whilst therapeutically desired, can occasionally be excessive) These effects typically diminish over several weeks as the body adjusts to the medication