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The GSTs belong to a superfamily of multigenic enzymes that catalyze the nucleophilic attack of the reduced form of Glutathione (GSH) to compounds that present a carbon, a nitrogen or an electrophilic sulfur atom [21]

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Systemic and endothelial inflammation contribute to collagen deposition, interstitial fibrosis and therefore atrial and ventricular remodelling as well as vascular stiffening [9, 10]

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