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It acts as a retrograde signal from mitochondria to the cell nucleus, activating the AMPK pathway, which is the master regulator of cellular energy balance

What makes Tirzepatide stand out is its ability to act on both receptors at the same time, creating a combined effect that leads to more significant weight loss than medications targeting only GLP-1

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While many of these platforms show promise in preclinical and early clinical studies, critical translational barriers remain