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Dis Model Mech 11(8):dmm035758 Mukhopadhyay S, Goswami D, Adiseshaiah PP et al (2020) Undermining glutaminolysis bolsters chemotherapy while NRF2 promotes chemoresistance in KRAS-driven pancreatic cancers
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Gln depletion therapy can inhibit Gln metabolism in tumor cells, but in colon cancer, it has been observed that Gln depletion promotes the expression of the aspartate/glutamate transporter SLC1A3 in tumor cells, increasing the intracellular glutamate concentration and promotes Gln synthesis
Retrieved July 15, 2026
The differences seen by income groups may be influenced by both the increased use of GLP-1 RAs during the study period (Rodriguez et al., 2023) and the change in clinical guidelines during the period (Summary of Revisions, 2020)
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