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Many patients do extremely well on the lower end when paired with a topical 2 %3 % serum and good sun protection

If the presence of an initial stressor is prolonged, the HPA axis will become chronically activated and trigger the overproduction of cortisol which, over time, will result in a reduction in cortisol levels (427)

Animal studies (Neelakantan et al., Biochemical Pharmacology, 2018) showed significant body fat reduction without changes in food intake

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In CKD of other aetiologies than CRN, CS is also a suggested pathomechanism [60]